SFB 1315: Mechanisms and disturbances in memory consolidation: From synapses to systems

该协作研究中心(CRC)专注于系统内存整合。也就是说，它不仅研究大脑中与记忆相关的结构如何保留长期信息，而且研究大脑如何将这些信息转化为与特定记忆相对应的事实、知识和技能。这一主题可以被视为脑研究的中心问题之一，也是CRC的理想主题，因为单独工作的实验室很难解决这一问题。第一轮合作伙伴关系会议非常成功，取得了许多突破并发表了许多成果。总体而言，该联盟提供了对海马体中起源的最终导致大脑皮层记忆的信号、这些信号到达哪里以及它们的作用是什么的洞察。这种基础性的研究已经改变了我们看待记忆整合的方式。对于我们的第二个资助期申请，我们确定了一些在第一轮中得到关注的主题。这些包括在海马体中产生的记忆相关活动的性质，从内侧颞叶到新皮质的信息传输，用于编码记忆的细胞集合的精细化(记忆编码)，睡眠的作用，记忆环路，以及大脑刺激如何影响记忆。我们介绍了三个新的科学项目，以加强成功的主题，并利用十个新的私人投资机构，他们要么已经到达柏林，要么与儿童权利委员会的目标保持一致。我们将扩大研究范围，既包括与记忆有关的分子事件，也包括记忆巩固的大规模动力学。为了做到这一点，我们引入了在本地蛋白质合成和动物行为的分子基础方面具有专业知识的新PI，以及在大型系统工作的临床、实验和理论领域的PI。对于第二轮，我们还将引入一个由皮里特领导的强大的基础设施项目，该项目将进一步发展这些可重复研究的战略，并将该联盟整合到德国和欧洲正在进行的数据管理倡议中。总而言之，CRC 1315最大限度地利用了柏林现有的神经科学社区正在研究记忆。

This Collaborative Research Center (CRC) focuses on systems memory consolidation. That is, it investigates not just how memory-related structures in the brain retain long-term information, but how the brain transforms this information into facts, knowledge and skills that correspond to specific memories. This topic can be seen as one of the central issues in brain research and it is also an ideal topic for a CRC because it is difficult to tackle by individual laboratories working alone. The first round of the CRC was very successful with many breakthroughs and publications. Overall, the consortium provided insight into what signals originate in the hippocampus that eventually lead to memories in the cortex, where these signals arrive and what their action is. This kind of foundational research has already changed the way we look at memory consolidation.For our second funding period application, we have identified a number of themes that were brought into focus during the first round. These include the nature of memory-related activity generated in the hippocampus, the transfer of information from the medial temporal lobe to neocortex, the refinement of ensembles of cells for encoding memories (engrams), the role of sleep, memory loops, and how brain stimulation influences memory. We introduce three new scientific projects to enhance the successful themes and take advantage of ten new PIs who have either arrived in Berlin or become aligned to the goals of the CRC. We will increase the range of investigations to include both molecular events related to memory and large-scale dynamics of memory consolidation. To do this, we have brought in new PIs with expertise in the molecular underpinnings of local protein synthesis and in animal behavior, as well as PIs in the clinical, experimental and theoretical domains working on large-scale systems. For the second round, we will also introduce a robust infrastructure project led by PI Ritter that will further develop these strategies for reproducible research and integrate the consortium into ongoing data management initiatives around Germany and Europe.In summary, the CRC 1315 takes maximum advantage of the existing neuroscientific community investigating memory in Berlin.