Morbillivirus Intra- and Inter-Host Dynamics and Genetic Plasticity (B09*)

该项目旨在通过确定新生突变和小种群重新出现的贡献，以及评估抗病毒治疗下准种变化和病毒适应度，来表征遗传可塑性在麻疹病毒发病机制中的作用。为此，我们使用犬瘟热病毒作为模型系统，因为我们观察到在感染的最后阶段，病毒接种量和靶组织中的种群之间存在明显差异。

This project aims at characterizing the role of genetic plasticity in Morbillivirus pathogenesis by determining the contribution of de novo mutations and re-emergence of minor populations, and assessing the quasispecies changes and viral fitness in the presence of antiviral therapy. Towards this, we use canine distemper virus as a model system, which causes a lethal disease in ferrets, since we observed distinct differences between virus inoculum and populations in target tissues at the end stages of infection.