Rhodium-catalyzed Desymmetrization of non-annulated Azanorbornadienes and Azanorbornenes

该项目旨在开发铑催化的非环状氮杂降冰片二烯和氮杂降冰片烯的去对称化。这种新方法赠款获得各种反式取代的氨基环己二烯和环己烯。除了广泛使用的氧和氮亲核试剂外，还将测试碳亲核试剂，以使芳基和烷基取代的产物可获得。通过使用双官能亲核试剂，可以合成迄今为止难以获得的几种手性碳环和杂环化合物。得到的结构基序不仅是有趣的合成各种天然产物，但也是广泛使用的过渡金属催化反应的配体的一部分。除了这些配体多样化的可能性，开发的方法能够合成手性吲哚啉，内酰胺或取代的氨基环庚烯。

The project aims at the development of a rhodium-catalyzed desymmetrization of non-annulated azanorbornadienes and azanorbornenes. This novel method grants access to a variety of trans-substituted amino cyclohexadienes and cyclohexenes. Apart from widely used oxygen and nitrogen nucleophiles, carbon nucleophiles are to be tested in order to render aryl and alkyl substituted products accessible. With the use of difunctional nucleophiles, the synthesis of several chiral carbo and heterocycles is enabled, which are difficult to access to date. The structural motifs obtained are not only interesting for the synthesis of a variety of natural products, but are also part of widely used ligands for transition metal catalyzed reactions. Aside from the possibility of diversification of these ligands, the developed method enables the synthesis of chiral indolines, lactams or substituted amino cycloheptenes.