Membrane protein organization studied at the single molecule level using liquid-phase electron microscope (C07)

ORAI1和HER2蛋白都控制肌动蛋白骨架的动力学，肌动蛋白骨架是负责细胞迁移的细胞结构的主要组成部分，在癌症转移等过程中起着关键作用。然而，潜在的机制，以及它们的相互依赖性仍然知之甚少。利用液相电子显微镜，我们研究了细胞如何在与肌动蛋白相关的功能配置的特定位置组织这些膜蛋白以调节功能的生物物理原理。

ORAI1 and HER2 proteins are both known to control the dynamics of the actin cytoskeleton, the main component of the cellular structure responsible for cell migration playing a pivotal role for instance in cancer metastasis. However, the underlying mechanisms, as well as their interdependencies are still poorly understood. Using liquid phase electron microscopy, we study the biophysical principles of how a cell or-ganizes these membrane proteins in specific locations in a functional configuration in relation to actin such to regulate function.