Ganzkörper Hybrid PET/MR Tomograph

由于形态、生理和分子成像的结合，全身PET/MR引起了人们的极大期望。第一代用户成功地评价了PET/MR的总体方面和可行性。最近，第二代扫描仪的推出有了实质性的改进。对于乌尔姆大学来说，这是加入PET/MR社区的理想时机，因为我们的临床和科学专业知识非常适合扩展PET/MR的智能和创新应用方面的知识。该系统将作为“核心设施”运行，因此将对各种项目进行调查。然而，来自临床和转化性研究的两个主要主题将是我们的重点：评估PET/MR的常规适应症，设计高效的工作流程，以促进诊所的整合。在这里，CCCU(综合癌症中心)的基础设施将特别有益。此外，对“多模式多参数成像”或“MMPI”概念的评估，即对组织生物学的多个定量数据的综合分析，可以由PET/MR非侵入性地提取并用于例如治疗计划、预后评估或反应评估。将形成以下6个项目领域：神经科学(A)、心血管科学(B)、肿瘤学(C)、儿科学(D)、传染病和肌肉骨骼疾病(E)以及核心项目医用物理和仪器(F)。在这些领域中的每一个领域，乌尔姆大学都有专门的专业知识，保证了PET/MR的成功实施和出色的科学产出。

Whole-body PET/MR raises great expectations due to the combination of morphological, physiological and molecular imaging. The first generation of users successfully evaluated the general aspects and feasibility of PET/MR. Recently, the second generation of scanners was introduced with substantial improvements. For Ulm University, this is the ideal time to join the PET/MR community, as our clinical and scientific expertise is well suited for extending the knowledge on intelligent and innovative applications of PET/MR. The system will be run as a “core facility”, thus a broad variety of projects will be investigated. However, two main topics from clinical and translational research will be in our focus: evaluation of routine indications for PET/MR with design of efficient workflows to facilitate integration in the clinics. Here, the infrastructure of the CCCU (comprehensive cancer center Ulm) will be especially beneficial. Moreover, evaluation of the concept of “multimodal multiparametric imaging” or “mMPI”, i.e. the integral analysis of the multiple quantitative data on tissue biology, which can be extracted non-invasively by PET/MR and be used e.g. for therapy planning, prognostic assessment or response evaluation. The following 6 project areas will be formed: Neurosciences (A), Cardiovascular sciences (B), Oncology (C), Pediatrics (D), Infectious and musculoskeletal diseases (E) and the Core project medical physics and instrumentation (F). In each of these areas, special expertise is present at Ulm University, guaranteeing a successful implementation of PET/MR with excellent scientific output.