Rhombomeric Topography of Structures in the Adult Mouse: Evidence from Avian Homologies and Transgenic Mice

鸟类的脑干被证明是由一排片段组成的，就像火车的车厢一样。哺乳动物的胚胎中也有同样的排列，但在成年哺乳动物的大脑中却不存在。我们将把我们对鸟类大脑的详细了解转移到绘制成年老鼠脑干部分的地图上。然后，我们将用特殊的基因标记来测试这张图，这将揭示成年小鼠的隐性节段模式。这项工作将为我们理解控制呼吸、心血管功能和情绪状态的脑干中心的组织提供一种新的方式。

The brainstem of birds has been shown to be formed by a line of segments, like carriages of a train. The same arrangement exists in the embryos of mammals, but is hidden in the adult mammalian brain. We will transfer our detailed knowledge of bird brains to make a maps of the brainstem segments in adult mice. We will then test this map with special gene markers which will reveal the occult segmental pattern in adult mice. This work will give us a new way of understanding the organisation of brainstem centres that control breathing, cardiovascular functions and emotional states.