Modular Synthesis of Organic Cage Compounds through Dynamic Covalent Chemistry

本项目的目标是基于合理和可预测的设计方法，模块化合成不同尺寸、形状和官能度的共价有机笼状化合物。在分子工具箱的基础上，通过各种单体亚组分的适当组合，人们可以轻松地访问集成结构。由于其定义的拓扑和坚固的结构，这些笼子允许不同功能的精确空间排列。作为实现这些目标的主要合成工具，我们希望既利用小分子前体的适当官能化，又利用组装的笼子的合成后修饰。笼腔内的反应位置的实现导致了定制的配位环境的形成，这应该被利用来与合适的客体分子或模板辅助的笼子组装进行特定的相互作用。此外，反应中心的面外附着可以导致单体笼状单元的特定交联性，尽管有助于更好地控制固态中的三维排列。

Aim of this project is the modular synthesis of covalent organic cage compounds with varying size, shape and degree of functionality based on a rational and predictable design approach. Based on a molecular tool box, one get easy access to integrative architectures by means of suitable combinations of various monomeric subcomponents. Due to their defined topology and rigid structures, these cages allow for a precise spatial arrangement of different functionalities. As the main synthetic tools to achieve these aims, we want to utilize both appropriate functionalization of the small-molecule precursors as well as post-synthetic modifications of the assembled cages. The implementation of reactive positions within the cage cavities leads to the formation of tailor-made coordination environments, which should be exploited for specific interactions with suitable guest molecules or the template-assisted assembly of the cages. Furthermore, the exohedral attachment of reactive sites can lead to the specific cross-linking of monomeric cage units though facilitating a better control over the three-dimensional arrangement in the solid state.