GRK 1029: Functional Genome research in veterinary medicine

在人类和小鼠获得全基因组序列后，基因和基因网络的功能分析将是基因组研究的下一个重要时代。与经典的测序项目相比，这需要更广泛的技术和方法。除了体内和体外模型系统的形态和功能表型的标准方法外，还需要在信使RNA(转录组)和蛋白质(蛋白质组学)水平上全面筛选基因活性的系统方法。基因功能的分析将在未来的家畜育种计划中发挥关键作用，可以预见，功能基因组研究将为一般动物疾病提供新的研究策略。这个研究培训小组的目的是将兽医、医学、生物化学、生物学、药剂学或农业等学科的顶尖毕业生聚集在一起，为他们提供这一具有前瞻性的生物医学研究领域的深入培训。该研究计划基于兽医学院成员与慕尼黑基因中心小组在“糖尿病模型”和“生长与分化”领域现有的卓有成效的合作。虽然研究计划集中在这两个领域，但方法的范围和被调查的物种(小鼠、猪、狗、牛、鸡)以及跨学科方法(分子动物育种、动物育种、生物化学、解剖学、生理学、病理学、药剂学、内科医学、实验动物科学、食品卫生和心理语言学)为出色的研究和培训提供了广泛的基础。因此，这个研究培训小组的研究和培训计划非常适合于提高青年科学家的职业发展，并在这一重要领域建立新的结构。

After the whole genome sequences have become available for man and mouse, the functional analysis of genes and gene networks is the next important era of genome research. This requires a broader spectrum of technologies and methods as compared to classical sequencing projects. In addition to standard methods for morphological and functional phenotyping of in vivo and in vitro model systems, systematic approaches for holistic screens of gene activities at the level of messenger RNA (transcriptomics) and proteins (proteomics) are needed. The analysis of gene functions will play a pivotal role in future livestock breeding programmes and it can be envisaged that functional genome research will offer new research strategies for animal diseases in general. It is the aim of this Research Training Group to bring together top graduates from the disciplines veterinary medicine, medicine, biochemistry, biology, pharmacy or agriculture, and to provide them with in-depth training in this forward-looking field of biomedical research. The research programme is based on existing and fruitful collaborations between members of the veterinary faculty and groups of the Munich Gene Centre in the fields of "diabetes models" and "growth & differentiation". Although the research programme is focussed on these two areas, the spectrum of methods and of investigated species (mouse, pig, dog, cattle, chicken), and the interdisciplinary approach (molecular animal breeding, animal breeding, biochemistry, anatomy, physiology, pathology, pharmacy, internal medicine, laboratory animal sciences, food hygiene, and psycholinguistics) provide a broad basis for excellent research and training. Thus, the research and training programme of this Research Training Group is highly suitable to improve the career advancement of young scientists, and to create new structures in this important area.