Targeting the mutanome of liver cancer by viral oncoly-sis and tumor-directed immunotherapies (C06+)

项目C06(Kühnel；通过病毒溶瘤和肿瘤导向免疫疗法针对肝癌的突变组)将分析在已实施的溶瘤病毒疗法和PD-1抑制的模型中，具有明确的CD4和CD8新表位谱的表位扩散。此外，还将分析病毒治疗后新表位特异性T细胞的反应模式以及免疫刺激转基因在表位扩散中的作用，以开发结合病毒治疗和检查点抑制的优化策略。

Project C06 (Kühnel; Targeting the mutanome of liver cancer by viral oncolysis and tumor-directed immunotherapies) will analyze epitope spreading in response to the already implemented oncolytic virotherapy and PD-1 inhibition in models with defined CD4- and CD8-neoepitope spectrum. Also neoepitope-specific T-cell response pattern after virolytic therapy and the effect of immunostimulatory transgenes in epitope spreading will be analyzed in this context in order to develop optimized strategies combining virotherapy and checkpoint inhibition.