The role of heparan sulfate proteoglycans during zebrafish bone regeneration (B11*)

F. Knopf和M.品牌专注于骨再生和糖皮质激素诱导的骨质疏松症（GIO）使用斑马鱼作为模型。他们的目标是研究FGF（成纤维细胞生长因子）信号通路和FGF与硫酸乙酰肝素蛋白聚糖（HSPG）的相互作用，并建立FGF形态发生梯度，因为它们对正常和增生性骨再生的重要性。这些结果提供了深入了解在成人创伤后骨再生过程中HSPG和FGF的相互作用及其受糖皮质激素的调节。

F. Knopf and M. Brand focus on the bone regeneration and glucocorticoid-induced osteoporosis (GIO) using zebrafish as a model. Their goals are to investigate the FGF (fibroblast growth factor) signaling pathway and the interaction of FGF with heparan sulfate proteoglycans (HSPG), and to establish FGF morphogenetic gradients, because of their importance for normal and osteoporotic bone regeneration. These results provide insights into the interaction of HSPG and FGFs during adult bone regeneration after trauma and its modulation by glucocorticoids.