NET - Genetics of PTSD: Genetic characteristics of patients with and without symptoms of post-traumatic stress disorder following an intensive care experience

NET- PTSD遗传学作为临床试验NET（叙述性暴露疗法）-初级保健-重症医疗后创伤应激后遗症患者的护理（DFG no. 5）的补充拨款申请提交。: GE2073)。该子研究的目的是确认并补充先前在重症监护病房（icu）招募的独特且特征明确的患者群体中与创伤后应激障碍（PTSD）症状相关的遗传发现。由于侵入性医疗程序、通气、无助感、噪音、灯光、睡眠节奏紊乱、对死亡的恐惧等，在ICU的治疗可能是一种非常令人不安的经历。因此，许多患者在出院后遭受长期的功能、医疗或心理后遗症。在精神疾病中，创伤后应激障碍具有独特的地位，因为它是唯一一种可以明确识别创伤暴露这一起始因素的疾病。许多基因可能与PTSD易感性增加有关。它们是非常可信的生物途径的一部分，显然在恐惧条件反射、焦虑行为和情绪方面发挥作用。涉及的调节系统包括下丘脑-垂体-肾上腺轴（HPA轴或HTPA轴：对压力的反应），大脑血清素能系统（情绪反应，焦虑）和多巴胺能神经传递（注意力，警觉性，觉醒和睡眠）。基因与环境的相互作用也很重要。我们的研究是第一个调查重症监护患者与非创伤后应激障碍患者的遗传差异的研究。

NET-Genetics of PTSD is submitted as a supplementary grant application to the clinical trial NET (Narrative Exposure Therapy) -primary care -Caring for patients with traumatic stress sequelae following intensive medical care (DFG no.: GE2073). The aim of the sub-study is to confirm and add to previous genetic findings associated with symptoms of posttraumatic stress disorder (PTSD) in a unique and particularly well characterized population of patients recruited at Intensive Care Units (ICUs). Treatment at an ICU can be a very disturbing experience due to invasive medical procedures, ventilation, the feeling of helplessness, noise, lights, a disordered sleep rhythm, fear of dying etc. Thus, many patients suffer from long-term functional, medical, or psychological sequelae after discharge. Among psychiatric disorders, PTSD has a unique position as it is the only disorder in which the initiating factor, the trauma exposure, can be unequivocally identified. A number of genes have been described which may be associated with an increased susceptibility for PTSD. They are part of very plausible biological pathways and apparently play a role in fear conditioning, anxiety behaviour and emotionality. Regulatory systems involved include the hypothalamic-pituitary-adrenal axis (HPA axis or HTPA axis: response to stress), the brain serotonergic system (emotional response, anxiety), and dopaminergic neurotransmission (attention, vigilance, arousal, and sleep). Gene-environment interactions are also of great importance. Our study is among the first to investigate the genetic distinctiveness of ICU-patients with PTSD compared to ICU-patients without PTSD.