Defining New Building Blocks for the Construction of Artificial Genetic Circuits

通过描述自然遗传开关的组件，我们将提供一组定义良好的遗传构建块，用于构建合理设计的生物电路。建造这种电路的能力将在代谢工程、提高从微生物中生产天然化合物的效率以及在生物医学中用于治疗性化合物的控制释放等领域产生显著的经济效益。荣誉和博士生参与这一项目将使下一代澳大利亚科学家接触到这一新兴学科。国际合作导致在高影响力的科学期刊上发表文章，这将提高澳大利亚的科学声誉。

By characterising the components of a natural genetic switch, we will make available a set of well defined genetic building blocks for construction of rationally designed biological circuits. The ability to build such circuits would have significant economic benefit in areas such as metabolic engineering, to improve the efficiency of production of natural compounds from micro-organisms, and in biomedicine, for the controlled release of therapeutic compounds. The involvement of Honours and Ph.D students in this project will expose the next generation of Australian scientists to this emerging discipline. International collaboration leading to publications in high impact scientific journals will enhance Australia's scientific reputation.