Development of liver tissue regeneration therapy using a novel low-power extracorporeal shock wave for treatment of liver cirrhosis

目前基本上还没有治疗肝硬变的灵丹妙药。预防并发症，有助于肝硬变的功能恢复是非常重要的。开发高效、微创的新治疗方法是人们迫切需要的。据报道，低功率体外冲击波照射缺血组织具有血管生成活性和抑制心肌重塑的作用。我们阐明了低功率体外冲击波治疗肝硬变的效果。在这项研究中，我们评估了动物模型的肝功能、细胞再生、纤维化程度、血管生成活性和不良事件。虽然小功率体外冲击波的照射是安全的，但仍需进一步考虑最佳条件和生物学机制。

There is no silver bullet of the treatment for liver cirrhosis currently and essentially. It is important to prevent the complications and help the function of the cirrhotic liver. Development of new treatments highly effective and minimally invasive is strongly desired. Angiogenic activity and inhibition of myocardial remodeling have been reported by irradiation of the low power extracorporeal shock wave to the ischemic tissue. We elucidate the effect of the low power extracorporeal shock wave for the liver cirrhosis. In this study, we evaluate the liver function, cell regeneration, degree of fibrosis, angiogenic activity and adverse events in the animal model using rat. Although the irradiation of the low power extracorporeal shock wave were performed safely, it is necessary to consider the optimum condition and the biological mechanism further more.