Free radical generation following shock liver

本研究旨在通过微透析技术研究休克后肝脏组织中羟基自由基（OH）和一氧化氮（NO）的生成。休克后1、7小时肝组织体内OH的生成增加。休克前给药氨基胍导致肝组织中几乎所有阶段NO的抑制和OH产物的减少。上述结果提示，如果能调控休克肝脏的iNOS，不仅可以控制肝脏NO的生成，还可以控制羟基自由基的产生。我们可以在急救和重症监护中减轻休克后的肝损伤。

The aim of this study was to investigate the generation ofhydroxylradical(OH) and nitric oxide (NO) in the hepatic tissue in vivo after in shock liver by using microdialysis technique. The generation of OH in the hepatic tissue in vivo increased at 1 and 7 hour after shock. The administration of aminoguanidine before shock caused the inhibition of NO and the reduction of OH products in the hepatic tissue at almost all phases.Thease results suggest that if we can regulate iNOS in shock liver, we can control not only the production of NO generation in the liver, but also the production of the hydroxyl radical. We may relieve a liver damage after the shock in the emergency and intensive care.