The involvement of Streptococcus anginosus infection and AID expression in oral cancers

血管链球菌感染可能与口腔鳞状细胞癌密切相关。最近的研究表明，上皮细胞中AID的异常表达可能导致肿瘤相关基因的核苷酸改变，并可能导致表达AID的细胞发生恶性转化。本研究评估了口腔癌中血管链球菌感染与aids表达的关系。口腔鳞状细胞癌中常检出血管支索菌DNA，且癌区AID表达较高。血管棘球蚴抗原刺激可诱导培养细胞内NF-kB的活化和AID的表达。综上所述，口腔鳞状细胞癌中血管链球菌感染可能与AID的表达密切相关。

Streptococcus anginosus infection could be closely related with oral squamous cellcarcinoma. Recent studies suggested that the aberrant expression of AID in the epithelial cells could re-sult in the generation of nucleotide alterations in tumor-related genes and possible malignant transforma-tion of the AID-expressing cells. In this study, the involvement of S. anginosus infection and the AID ex-pression in oral cancers was assessed. S. anginosus DNA was frequently detected in the oral squamous cell carcinoma, and the relatively higher AID expressions were observed in the cancerous region. The stimula- tion with S. anginosus antigens could induce the NF-kB activation and AID expression in cultured cell li- nes. Taken together, S. anginosus infection could be closely related with the AID expression in the oral squamous cell carcinoma.