Development of model mouse series by dividing multi functions of transcriptional co-repressor

为了了解无毛（Hr）在代谢中的功能，我们试图开发一种新的模型小鼠系列，其中Hr基因以组织特异性的方式有条件地靶向或过表达。利用Cre-loxP系统，我们培育了Hr基因的条件敲除小鼠和条件过表达Hr基因的CAG-loxP-CAT-pA-loxP-Hr转基因小鼠。我们还开发了骨骼肌特异性Cre小鼠，表达由肌酸激酶驱动的Cre重组酶。利用这些转基因小鼠，我们产生了针对骨骼肌的特定Hr

To understand the function of Hairless (Hr) in metabolism, we tried to develop a novel model mouse series in which Hr gene is conditionally targeted or over-expressed in a tissue-specific manner. Using Cre-loxP system, we developed conditional knockout mice of Hr gene, and CAG-loxP-CAT-pA-loxP-Hr transgenic mice that conditionally overexpress Hr gene. We also developed skeletal muscle specific Cre mice expressing Cre recombinase driven by Creatine kinase, muscle promoter. Using these genetically modified mice, we generated skeletal muscle specific Hr targeted