Investigation on the usefulness of extracellular circulating microRNAs as a biomarker for the plasticity of skeletal muscle

本研究的目的是评估细胞外循环microRNAs（miRNAs）作为骨骼肌可塑性生物标志物的有效性。血浆中四种miRNA的响应与骨骼肌质量中miRNA表达的变化相对应。卸载相关骨骼肌萎缩后，观察到75种血浆miRNA的特异性变化。在卸载相关萎缩骨骼肌再生过程中检测到血浆中7种miRNAs的变化。这86个miRNA可能是骨骼肌可塑性生物标志物的候选者。有证据表明，细胞外循环miRNA可能是骨骼肌可塑性的生物标志物。

The purpose of this study was to evaluate the usefulness of extracellular circulating microRNAs (miRNAs) as a biomarker for the plasticity of skeletal muscle. Response of four miRNAs in plasma corresponded with the changes in miRNA expressions in skeletal muscle mass. Specific chnages of seventy-five plasma miRNAs was observed following unloading-associated skeletal muscle atrophy. Changes in plasma seven miRNAs were detected during the regrowth of unloading-associate atrophied skeletal muscle. These eighty-six miRNAsmight be candidates for a biomarker for the plasticity of skeletal muscle. Evidences suggest that extracellular circulating miRNA(s) may be useful for a biomarker(s) for the plasticity of skeletal muscle.