Function-determining Excited-State Dynamics in Transition-Metal Complex-Based Photodrugs in a Cellular Environment

当代对过渡金属络合物的光物理和光化学的研究涉及将这些体系作为光活性药物的研究。除了与设计基于新型过渡金属络合物的光药物及其预期的应用相关的大量合成、生物和药理学挑战外，例如作为抗炎或抗癌药物，一个中心的光物理问题是普遍存在的：生命细胞中的局部环境(或者更具体地说，在细胞的特定间隔中)如何影响这种过渡金属络合物中决定光诱导激发态动力学的超快功能？该项目将开发实验光谱工具，并与统计数据分析程序携手回答这一核心问题。为了破译细胞内配合物的超快光诱导过程而采取的步骤将是理解这类光活性金属配合物的结构-动力学-功能关系的内在重要的下一步光物理步骤。

Contemporary research on photophysics and photochemistry of transition metal complexes involves the investigation of these systems as photoactive drugs. In addition to the plethora of synthetic, biological and pharmacological challenges associated with the design of novel transition metal complex-based photodrugs and their anticipated application, e.g., as anti-inflammatory or anti-cancer drugs, a central photophysical question is prevalent: How does the local environment in a life cell (or even more specifically: in specific compartments of a cell) impact the ultrafast function-determining photoinduced excited-state dynamics in such transition metal complexes? This project will develop experimental spectroscopic tools hand in hand with routines for statistical data analysis to answer this central question. The steps to be taken towards deciphering the ultrafast photoinduced processes of complexes inside cells will present the inherently important next photophysical step towards understanding the structure-dynamics-function relationship in this class of photoactive metal complexes.