Models for connecting mechanics at cell and tissue scales

由于难以直接测量在生长组织中起作用的力，因此在动物身体的形态发生中，机械力是如何调节以实现变形的仍然没有很好地理解。我们发展了一种从细胞形状推断力的理论方法。我们验证了我们的方法与激光烧蚀实验比较的准确性和鲁棒性，也比较其他推理方法。通过将我们的方法应用于果蝇上皮组织，我们比较了各个组织中细胞的机械特征如何导致组织的不同和特征行为。

Because of difficulty in directly measuring forces working in growing tissues, how mechanical forces are regulated for achieving deformation of animal body in their morphogenesis is still not well understood. We have developed a theoretical method for inferring the forces from shape of cells. We verified the accuracy and robustness of the method by performing comparison of our method with laser-ablation experiments, and also comparison among other inference methods. By applying our method to Drosophila epithelial tissues, we compared how mechanical features of cells in respective tissues can results in distinct and characteristic behaviors of the tissues.