Studies on ammonia exposure to trichothecene mycotoxin, deoxynivalenol

进行了研究，以确定氨暴露于黑藻烯真菌毒素，脱氧雪腐镰刀菌烯醇（DON）的影响。氨暴露可使DON浓度呈剂量依赖性降低。DON可逆地和不可逆地通过短时间（24小时）的氨化作用转化。相反，氨化3周后，DON未被完全检测到。DON-NH_3反应液对人白血病细胞株HL_（60）作用24 h后有细胞毒性，作用3周后无细胞毒性。

Research was conducted to determine the effect of ammonia exposure to trichothecene mycotoxin, deoxynivalenol (DON). DON concentration decreased by ammonia exposure in a dose dependent manner. DON was transformed both reversibly and irrevesibly by a short period (24 h) of ammoniation. In contrast, after 3 weeks ammoniation, DON was not detected completely. Cytotoxicity to human leukemia cell line HL60 by DON-NH3 reacted solution was present after 24 h reaction, but not detected any toxicity after 3 week reaction.