Trends in Intraparenchymal Hemorrhage Subtypes and Its Risk Factors.

对1986 - 2010年日本3个社区的肝实质内出血（IPH）发生率进行系统监测。1986 - 2010年，深部IPH的发病率呈上升趋势，而大叶性和小脑性IPH的发病率基本持平。一项针对年龄在40-69岁之间的日本受试者的前瞻性研究，使用了1985年至1994年间在三个社区进行的心血管风险调查中收集的9086名参与者的数据。通过系统监测确定1985 - 2010年IPH发病率。在平均20.5年的随访期间，发生了144次iph事件。收缩压、体重指数、心电图主要ST-T异常和过量乙醇摄入（>=46g/天）与深部脑出血风险增加相关，而血清总胆固醇水平与脑叶和小脑IPH发生率呈负相关，即使在调整了潜在的混杂变量后也是如此。

The incidence of intraparenchymal hemorrhage (IPH) from 1986 to 2010 was ascertained by systematic surveillance in three Japanese Communities. The incidence of deep IPH has tended to have increased from 1986 to 2010, while the incidence of lobar and cerebellar IPH has been flat.A prospective study of Japanese subjects aged 40-69 years was undertaken using data collected from 9,086 participants in cardiovascular risk surveys conducted in three communities between 1985 and 1994. The incidence of IPH between 1985 and 2010 was ascertained by systematic surveillance. During an average follow up of 20.5-years, 144 incident IPHs occurred. Systolic blood pressure, body mass index, major ST-T abnormality on electrocardiogram, and excess ethanol intake (>=46g/day) were associated with increased risk of deep ICH, while serum total cholesterol levels were inversely associated with incidence of lobar and cerebellar IPH, even after adjustment for potential confounding variables.