Identification of novel transporter for exporting iron to establish effective therapy for chronic liver disorder

由于体内过量的铁积累引起氧化应激，需要有效的铁排泄系统。令人惊讶的是，在这个系统中只发现了一种名为FPN1的分子。在这项研究中，我们旨在通过关注在抗氧化应激基因诱导中起核心作用的Nrf2调控表达的基因来鉴定新的铁输出蛋白。通过微阵列分析，列出了SLC40A1、HFE、FECH、CYBRD1、ISCU、SLC25A37和TFRC等候选蛋白，但它们都不具有铁出口活性。

As excess iron accumulation in body cause oxidative stress, it is needed that effective iron excretion system. Surprisingly, there is only one molecule named FPN1 has been identified in this system. In this study, we aimed to identify novel iron exporting protein by focusing on the genes that expressions are regulated by Nrf2 having central role for anti-oxidative stress gene induction. By using microarray analysis, some candidates such as SLC40A1, HFE, FECH, CYBRD1, ISCU, SLC25A37 and TFRC were listed up, however, all of those did not have iron exporting activity.