Harnessing tissue homeostasis-promoting functions of specialized regulatory T cells in graft-versus-host disease (B08)

调节性T细胞(Treg)具有两种不同的功能：它们维持自身耐受，并通过分化为特化组织Treg细胞来支持组织修复和器官动态平衡。我们的目标是利用组织Treg细胞的组织修复功能来预防或治疗异基因骨髓移植后的移植物抗宿主病。在这方面，我们希望确定组织修复因子，并将设计和研究用于GvHD治疗的“组织智能”Treg细胞。我们将把这些发现转化为人类Treg细胞，以建立新的Treg细胞治疗模式。

Regulatory T cells (Treg) perform two distinct functions: they maintain self-tolerance and support tissue-repair and organ homeostasis by differentiation into specialized tissue Treg cells. We aim to harness the tissue-repair function of tissue-Treg cells to prevent or treat graft-versus-host disease after allogeneic bone marrow transplantation. In this respect, we want to identify tissue-repair factors and will engineer and study ‘tissue smart’ Treg cells for the therapy of GvHD. We will translate these findings to human Treg cells to establish novel Treg cell therapy formats.