Mechanism of atherosclerosis progression by platelet-derived inflammatory cytokines in carotid artery stenosis

本研究揭示了剪切诱导的血小板源性炎性细胞因子，如sCD 40 L，白细胞介素，以时间依赖性的方式增加。在颈动脉狭窄患者中，与无糖尿病患者相比，观察到血小板源性炎性细胞因子的显著时间依赖性增加。针对颈动脉狭窄患者的临床研究旨在阐明心血管事件、斑块体积、血脂比值和炎性细胞因子值显示，发生脑血管事件的患者炎性细胞因子值显著升高和易损斑块患者。其作用机制和细胞内信号转导机制尚在研究中。其中一些内容已在期刊中报道（J Stroke Cerebrovasc Dis. 2012）。

This study revealed that shear-induced platelet-derived inflammatory cytokines, such as sCD40L, interleukins, increase in time-dependent manner. In carotid stenosis patients, a significant time-dependent increase of platelet-derived inflammatory cytokines was observed in the patients with diabetes compared to the patient without it. The clinical study for the patients with carotid artery stenosis to elucidate the correlation between cardiovascular events, plaque volume, and lipid ratio and inflammatory cytokines value revealed that the value of inflammatory cytokines are significantly high in the patients developed cerebrovascular event and the patients with vulnerable plaque. About its mechanism and its intracellular signal transduction are still under consideration. Some of these content has been already reported in journals(J Stroke Cerebrovasc Dis. 2012).