The role of Lefty1 expression cells during the ES cell self-organization.

位置信息的获取是构造复杂人工器官的关键。在小鼠胚胎中，Lefty1在左右轴和前后轴形成过程中起关键作用。并且，已知Lefty1在胚胎干细胞中表达。在本研究中，我试图揭示Lefty1表达细胞在ES细胞自组织中的作用。因此，对集落形成过程中表达Lefty1的细胞进行延时观察发现，Lefty1的表达始于ES集落的边缘细胞。而lefty1,2空ES细胞通常形成集落。接下来，我将揭示lefty1,2 null胚胎干细胞形成胚状体的方式。

The acquirement of positional informations is essential for the making of structurally-complicated artificial organs. In mouse embryos, Lefty1 is a key player during the Left-right and anterior-posterior axis formation. And, it is known that Lefty1 is expressed is ES (Embryonic Stem) cells. In this study, I have tried to reveal the role of Lefty1 expression cells in the self-organization of ES cells.As a result, time-lapse observations of Lefty1 expressing cells in the formation of colony showed that the expression of Lefty1 started in edge cells of the ES colony.And, Lefty1,2 null ES cells normally formed colonies. Hereafter, I'm going to reveal which do Lefty1,2 null ES cells form embryoid bodies.