The role of local tumor barrier function for tumor cell plasticity, invasion and metastasis of colorectal cancer (C11*)

申请人先前的工作表明，微生物组成为结直肠癌发生的主要调节因子。为了更详细地了解这种相互作用，他们将探索肿瘤屏障功能和微生物群如何参与大肠癌EMT和转移形成的调节。因此，他们将分析浸润免疫细胞和肠道植物群对肿瘤微环境和肿瘤细胞内在信号传导事件的影响，以了解导致结直肠癌EMT和转移的转移前小生境形成的启动。

Previous work of the applicants had shown that the microbiome emerged as a major regulator of colorectal carcinogenesis. To understand this interaction in more detail, they will explore how the tumor barrier functionality and the microbiota are involved in the regulation of EMT and metastasis formation in colorectal cancer. Thus, they will analyze the impact of infiltrating immune cells and the gut flora on both the tumor microenvironment and tumor cell intrinsic signaling events to understand the initiation of pre-metastatic niche formation that leads to EMT and metastasis in colorectal cancer.