Control of T cell motility by the biophysical properties of the tumor stroma (C10*)

本项目将研究肿瘤相关成纤维细胞对ECM重塑的影响及其对T细胞浸润的影响。乳腺癌、胃肠道和皮肤鳞状细胞癌将被用作工作模型。T细胞和癌细胞之间的物理接近是T细胞介导的杀伤所必需的。因此，了解ECM的生物物理特性及其对T细胞在肿瘤微环境中向肿瘤细胞迁移和浸润能力的影响将是优化T细胞治疗的最终目标。

This project will study the impact of tumor-associated fibroblasts on ECM remodeling and its influence on T cell infiltration. Breast, gastrointestinal and cutaneous squamous cell cancers will be used as working models. Physical proximity between T cells and cancer cells is required for T cell-mediated killing. Therefore, to understand the biophysical properties of the ECM and its influence on T cell migration and infiltration ability in the tumor microenvironment towards the tumor cells will be the ultimately goal to optimize T cell-based therapies.