Hyaluronic acid-based bioink platform with multi-functional crosslinkers for the controlled differentiation of mesenchymal stem cells (A02)

透明质酸（HA）代表人细胞外基质的主要组分，然而，到目前为止，缺乏用于生物织物的高度通用的基于HA的材料。该项目的总体目标是开发一种基于HA的生物墨水平台，该平台利用多功能交联剂（PEG，改性生物聚合物），能够控制间充质干细胞的分化。用肽和生长因子进行修饰以及加工成梯度材料将进一步促进打印的3D构建体内连贯组织的发育。从长远来看，这项工作的目标是生成生物墨水，用于开发临床相关的组织模型。

Hyaluronic acid (HA) represents a major component of the human extracellular matrix, however, so far highly versatile HA-based materials for biofabrication are lacking. The overall aim of this project is to develop a HA-based bioink platform utilizing multi-functional crosslinkers (PEG, modified biopolymers) that enables the controlled differentiation of mesenchymal stem cells. The modification with peptides and growth factors as well as the processing into gradient materials will further promote the development of coherent tissues within the printed 3D constructs. For the long term, this work aims to generate bioinks for the development of clinically relevant tissue models.