Development of Noninvasive Ultrasonic Measurement Device for Visco-elastic Properties of Vessel Wall

为了无创地测量包括深主动脉在内的人体动脉的弹性特性，我们研制了一种与截面回波描记术相连接的新型回波跟踪装置。该装置对脉动直径变化（D）的精度<delta>&lt;10^（-3）&gt; mm，对直径（D）的精度约为0.5mm，足以测量动脉壁的粘弹性。用该超声装置无创测量了61例健康人（20-89岁）腹主动脉的压力应变弹性模量（Ep），从<delta>D、D和听诊法测得的血压。平均Ep值为2.1 x &lt;10^6&gt;达因/ &lt;cm^2&gt;。Ep随年龄增长而显著增加（p&lt;0.001），回归方程为Ep=（-0.72+0.058 ×年龄）× 10^6达因/cm ~ 2（r=0.73）。在对4名健康人主动脉至肱动脉和腘动脉的动脉树弹性特性的系统测量中， ...更多信息 Ep值在动脉外周部位升高。在年龄匹配的42名健康受试者和32名冠状动脉疾病（CAD）患者（40-60岁）的测量中，Ep分别为0.99和1.83 x &lt;10^6&gt; dyne/ &lt;cm^2&gt;。冠心病患者腹主动脉的狭窄程度也明显高于正常人（P&lt;0.001）。冠心病患者Ep值与血总胆固醇值呈显著正相关（P&lt;0.01）。加速因素如冠状动脉危险因素被怀疑也会影响主动脉硬化的进展。此外，利用该装置并结合导管尖端微压计测量血压，通过计算机系统，从压力-半径关系中的滞后回线面积获得了14例受试者在体主动脉的粘弹性。测得的粘度系数（<eta>）为2.34 x &lt;10^6&gt;达因·s/ &lt;cm ^2&gt;，粘性损耗模量（<eta><omega>）为1.83 x &lt;10^6&gt;达因/ &lt;cm ^2&gt;，相位角（<phi>）为0.087弧度，Ep为2.02 x &lt;10^6&gt;达因/ &lt;cm ^2&gt;。少

To measure noninvasively the elastic properties of in vivo human arteries including deep aorta, which had not been able to be measured hitherto, a new echo tracking device linked to cross-sectional echography was deyeloped. The accuracy of the device for pulsatile diameter change( <delta> D) was <10^(-3)> mm and for diameter(D) was around 0.5mm respectively, and was sufficient to measure the visco-elastic properties of arterial wall. The pressure strain elastic modulus (Ep) of the abdominal aorta were noninvasively measured in 61 healthy subjects(20-89 years) with this ultrasonic device from <delta> D, D and blood pressure obtained by auscultatory method. The mean Ep value was 2.1 x <10^6> dyne/ <cm^2> . Ep was significantly increased with age(p<0.001), The regression equation relating Ep to age was Ep=(-0.72+0.058 x age)x <10^6> dyne/ <cm^2> (r=0.73). In the systemic measurement of elastic properties in arterial tree from aorta to brachial and popliteal artery in 4 healthy subjects, t … More he elevation of Ep value was found in the peripheral site of the artery. In the measurement of age-matched 42 healthy subjects and 32 patients with coronary artery disease(CAD)(40-60 years), Ep was 0.99 and 1.83 x <10^6> dyne/ <cm^2> respectively. A significant sclerotic change(p<0.001) was found also in the abdominal aorta in CAD patients compared with normal subjects. A significant correlation(p<0.01) between Ep value and the value of blood total cholesterol was found in the CAD patients. Accelerating factor like a coronary risk factor was suspected to influence also the progression of aortic sclerosis. Furthermore, with the device and the additional use of catherter tip micromanometer for blood pressure measurement, visco-elastic properties of aorta in vivo were obtained in 14 subjects from the area of the hysteresis loop in the pressure-radius relationship with computer system. Coefficient of viscosity( <eta> ) 2.34 x <10^4> dyne.s/ <cm^2> , viscous loss modulus( <eta> <omega> ) 1.83 x <10^6> dyne/ <cm^2> , and phase angle( <phi> ) 0.087 radian, Ep 2.02 x <10^6> dyne/ <cm^2> were obtained. Less