An idea of regulatory science-based bone regeneration product for critical bone defect healing

种植后4周和8周，对小鼠牙槽骨缺损模型的颌骨进行Micro-CT扫描和组织学分析，以评估缺损区的新骨形成。3D图像分析和苏木精和伊红染色的结果表明，植入的MCOB-3DPL结构在骨缺损内成功再生骨，并且在植入后8周显著高于其他组。纳米压痕分析表明，MCOB-3DPL构建体诱导的再生骨具有与天然骨相当的微观力学性能，种植体治疗的Micro-CT和组织学分析结果表明，MCOB-3DPL构建体诱导的再生骨具有骨整合能力。

The jawbones from the mice alveolar bone defect models were examined by Micro-CT scanning and histological analysis to assess new bone formation in the defect area at 4 and 8 weeks after implantation. The results of 3D image analysis and Hematoxylin and Eosin staining demonstrated that implanted MCOB-3DPL constructs have successfully regenerated bone within bone defects and is significantly higher than the other groups at 8 weeks post-implantation. Nanoindentation analysis has shown that regenerated bone induced by MCOB-3DPL constructs has micromechanical properties comparable to the native bone.The results of implant therapy by Micro-CT and histological analysis revealed that regenerated bone formed by MCOB-3DPL constructs possesses osseointegration ability.