Extracellular vesicles induced by innate immune pathways in cancer immunosurveillance (P14)

分泌的细胞外囊泡（EV）正在成为肿瘤微环境中细胞间通讯的重要机制。调节这种EV的生物发生和通常免疫抑制功能的肿瘤细胞中的异常免疫信号传导途径仍然未知。由于我们最近发现IFN-1偶联途径在调节癌症免疫监视中的癌症内在作用，我们在此旨在了解肿瘤内在胞质RIG-1和STING在免疫原性EV的产生和功能中的作用，以影响癌症免疫监视和治疗。

Secreted extracellular vesicles (EVs) are emerging as an important mechanism of intercellular communication in the tumour microenvironment. Aberrant immune signalling pathways in tumour cells that regulate the biogenesis and often immunosuppressive function of such EVs remain unknown. Led by our recent discoveries about cancer-intrinsic roles of IFN-I-coupled pathways in modulation of cancer immunosurveillance, we here aim to understand the role of tumour-intrinsic cytosolic RIG-I and STING in the generation and function of immunogenic EVs to influence cancer immunosurveillance and -therapy.