The interplay of EBV-induced γδ and αβ T cells during chronic EBV reactivation, PTLD, and EBV-directed cellular therapy in transplant recipients (B11*)

eb病毒（EBV）是移植后慢性感染和肿瘤的病因。虽然对适应性抗ebv T细胞反应有了大量的了解，但最近的结果表明，先天T细胞免疫在移植后病毒感染中起着关键作用。本项目旨在通过功能表征和下一代测序技术，了解EBV诱导的先天（γδ）和适应性（αβ） T细胞免疫在免疫正常和免疫抑制患者感染EBV时的相互作用，在单细胞水平上表征EBV诱导的免疫T细胞网络。最后，分析参数将转化为接受ebv特异性T细胞转移的患者，旨在改善过继性抗ebv T细胞治疗概念。

Epstein Barr Virus (EBV) is the cause for chronic infection and tumors after transplantation. While enormous insights have been gained into adaptive anti-EBV T cell responses recent results suggest a pivotal role of innate T cell immunity in viral infections after transplantation. This project aims at understanding the interplay of innate (γδ) and adaptive (αβ) EBV-induced T cell immunity during EBV infection in immunocompetent and immunosuppressed patients through functional characterization and next generation sequencing technologies to characterize the immune EBV-induced T cell network on single cell level. Finally, analyses parameters will be translated to patients receiving EBV-specific T cell transfer aiming at improving adoptive anti-EBV T cell therapy concepts.