The role of lysosomal cathepsins in α-synuclein metabolism and Parkinson’s disease (B11*)

该项目涉及溶酶体蛋白在帕金森病中的作用，其特征是α-突触蛋白从可溶的突触蛋白转化为不可溶的淀粉样蛋白纤维，并伴随着多巴胺能神经元的退化。将研究α-突触核蛋白与溶酶体组织蛋白D、B和L的相互作用，参与α-突触核蛋白的溶酶体降解。利用iPS细胞衍生的多巴胺能神经元，将检测患者组织蛋白的突变，并将组织蛋白D、B和L作为帕金森氏病的治疗靶点进行分析。

The project deals with the role of lysosomal proteases in Parkinson’s disease, which is characterized by conversion of α-synuclein from a soluble synaptic protein into insoluble amyloid fibrils accompanied by degeneration of dopaminergic neurons. The interplay of α-synuclein with lysosomal cathepsins D, B and L, involved in lysosomal degradation of α-synuclein, will be studied. Using iPS cell derived dopaminergic neurons, patient mutations in cathepsins will be examined, and cathepsins D, B and L will be analyzed as therapeutic targets in Parkinson’s disease.