Functional role of meprin β in Alzheimer’s disease (A15*)

该项目分析了meprin β在淀粉样蛋白生成途径中的参与。Meprin β在体外产生N-末端截短的Aβ肽。本文将阐述meprin β在神经元、星形胶质细胞和小胶质细胞中与体内Aβ肽生成有关的生理功能。使用细胞特异性meprin β-过表达小鼠，将分析APP的蛋白水解加工如何由meprin β和BACE 1以及竞争性α-分泌酶ADAM 10协调，以及meprin β是否参与阿尔茨海默病的发病和进展。

The project analyzes the involvement of meprin β in the amyloidogenic pathway. Meprin β generates N-terminally truncated Aβ peptides in vitro. The physiologic function of meprin β in neurons, astrocytes and microglia cells with regard to Aβ peptide generation in vivo will be addressed. Using cell-specific meprin β-overexpressing mice, it will be analyzed how the proteolytic processing of APP is orchestrated by meprin β and BACE1 and the competitive α-secretase ADAM10, and whether meprin β is involved in the onset and progression of Alzheimer's disease.