Biomimetic lipidic self-assembly materials for protein encapsulation

本项目旨在提高对蛋白质与脂质材料相互作用的认识，以指导新型生物材料的开发。蛋白质和多肽在药物、疫苗和诊断方面发挥着越来越重要的作用。然而，这些脆弱的、通常较大的大分子给药物输送带来了挑战。脂基材料是包封功能活性蛋白的理想基质。它们还具有作为药物递送载体的优点，包括控制释放特性。这些策略的结合为蛋白质治疗创造了一个理想的递送系统。该项目旨在描述蛋白质和脂质基质之间的物理化学相互作用。这可能会指导新型脂质材料的开发，用于蛋白质治疗药物的包封和控释。

This project intends to improve understanding of the interactions between proteins and lipidic materials to guide the development of new biomaterials. Proteins and peptides play an increasingly important role as drugs, vaccines and diagnostics. However, these fragile, often large, macromolecules come with challenges for drug delivery. Lipid-based materials are ideal matrices for encapsulation of functionally active proteins. They also offer advantages as drug delivery vehicles including controlled release properties. The combination of strategies creates an ideal delivery system for protein therapeutics. The project aims to characterise the physicochemical interactions between the protein and the lipid matrix. This may guide the development of novel lipidic materials for the encapsulation and controlled release of protein therapeutics.