(Patho-) physiology of resident PDGFRβ+ interstitial cells in the kidney (B01)

肾间质的主要细胞群由表达β类型的血小板衍生生长因子受体(β)的常驻细胞组成。尽管这些细胞非常丰富，但它们的特征还不是很好。该项目旨在根据亚群描述肾脏PDGFRβ+细胞库的特征。我们将探索PDGFRβ+细胞的结构和功能亚群、主要信号通路以及与正常肾功能、肾脏发育和肾脏疾病进展的相关性。预期的结果可以帮助建立新的概念，即驻留间质细胞的调节如何成为减缓肾脏疾病进展的策略。

A major cell population of the renal interstitium consists of resident cells expressing the β-type receptor for platelet-derived growth factor (PDGFRβ). Although highly abundant, these cells are not yet well characterized. This project aims to characterize the pool of renal PDGFRβ+ cells according to subpopulations. We will explore the structural and functional subpopulations, major signaling pathways as well as the relevance of PDGFRβ+ cells for normal kidney function, renal development, and progression of kidney diseases. The expected results can help to establish new concepts of how the modulation of resident interstitial cells could be a strategy to slow down the progression of kidney diseases.