Lipid dependence of signaling at curved membrane microcompartments (P22*)

项目P22将研究膜特性的变化如何影响脊椎动物细胞中弯曲质膜微区室的信号传导。为了确定膜对曲率依赖性信号传导的贡献，该小组的目标是表征（i）脂质组成的变化如何影响生物物理膜特性，如微粘度，刚度或张力，（ii）膜特性的变化如何影响曲率依赖性蛋白质动力学，以及（iii）曲率依赖性蛋白质recuplant的变化如何调节细胞信号传导和功能。

Project P22 will investigate how changes in membrane properties affect signaling at curved plasma membrane microcompartments in vertebrate cells. To determine the membrane contribution to curvature-dependent signaling, the group aims to characterize (i) how changes in lipid composition affect biophysical membrane properties such as microviscosity, rigidity or tension, (ii) how changed membrane properties influence curvature-dependent protein dynamics, and (iii) how changes in curvature-dependent protein recuitment regulate cell signaling and function.