GRK 2599: FAIR - Fine-Tuners of the Adaptive Immune Response

拟议的研究培训小组的目标是建立一个具有国际竞争力的研究和培训计划，以促进免疫学领域的年轻科学家和医学生。使用全基因组转录组分析，现代成像技术，转基因小鼠技术和CRISPR介导的基因组编辑对定义的分子调节剂进行分析，将识别和表征适应性免疫应答和免疫记忆的新微调器。为了实现我们的目标，我们从弗里德里希-亚历山大-埃尔朗根-纽伦堡大学（FAU）的8个研究所和临床部门招募了5名女性和12名男性研究人员，他们在适应性免疫领域具有国际公认的专业知识。所有研究人员都得到第三方资金的支持，并在研究生培训方面经验丰富。我们还为Rer博士提供创新的培训计划。获得生命科学硕士学位的候选人。该计划包括双周RTG保罗-埃利希俱乐部，研究特定以及跨学科的硬技能和软技能研讨会，内部RTG研究务虚会和RTG网络会议，RTG演讲嘉宾系列，以及RTG的公共关系计划。此外，我们还开发了一个快速通道计划，将导致六名研究员与学士学位的博士。国家学位，而不需要获得硕士学位。在为期一年的资格认证阶段，快速通道候选人将为他们的论文阶段做准备，并在硕士课程“综合免疫学”中接受分子生物学和免疫学方面的广泛培训，参加RTG特定活动，并参加德国以外实验室的研究型轮换。为了激励医学生进行基础研究，我们将建立一个创新和结构化的18个月的博士课程。该计划的亮点是一个为期8个月的实验室阶段，并根据每个医学生的教育需求量身定制的课程。一个由三名成员组成的论文咨询委员会将指导所有博士候选人完成整个论文项目。为了在国际上定位我们的博士生，他们将组织第七届国际RTG研讨会“适应性免疫调节剂”，并在德国以外的实验室进行研究轮换。我们相信，我们的创新培训和研究理念与假设驱动的项目将更好地准备我们的博士生为专业的研究生职业生涯作为免疫学家，并帮助他们发展成为批判性思维的科学家，在3-4年内完成他们的论文，并建立一个国际网络。

The goal of the proposed Research Training Group is to establish an internationally competitive research and training program to promote young scientists and medical students in the field of immunology. The analysis of defined molecular regulators using genome-wide transcriptome analysis, modern imaging techniques, transgenic mouse technologies and CRISPR-mediated genome editing will identify and characterize new fine-tuners of adaptive immune responses and immune memory. To reach our goal, we have recruited five female and 12 male researchers with an internationally recognized expertise in the field of adaptive immunity from eight institutes and clinical departments at the Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU). All researchers are supported by third-party funding and experienced in graduate training. We also offer an innovative training program for Dr. rer. nat. candidates with a master’s degree in life sciences. This program consists of a bi-weekly RTG Paul-Ehrlich-Club, research-specific as well as interdisciplinary hard skill and soft skill workshops, internal RTG research retreats and RTG network meetings, the RTG guest speaker series, and the RTG’s public relation program. Furthermore, we have developed a fast-track program that will lead six fellows with a bachelor’s degree to the Dr. rer. nat. degree without the need to obtain a master’s degree. During their one-year qualification phase, the fast-track candidates will be prepare for their dissertation phase and receive extensive training in molecular biology and immunology within the Master’s program “Integrated Immunology,” attend RTG-specific events, and participate in a research-oriented rotation in a laboratory outside of Germany. To motivate medical students for basic research, we will set up an innovative and structured 18-month-long doctoral program. Highlights of this program are an 8-month lab phase and a curriculum tailored to the educational needs of each medical student. A three-member thesis advisory committee will mentor all doctoral candidates through-out their entire thesis project. To internationally position our doctoral candidates, they will organize the 7th International RTG Symposium on "Regulators of Adaptive Immunity" and do research rotations in laboratories outside of Germany. We are convinced that our innovative training and research concept with hypothesis-driven projects will better prepare our doctoral candidates for a professional post-graduate career as an immunologist and help them to develop into critically thinking scientists, to complete their thesis in 3-4 years, and to build an international network.