VRE Network Baden-Württemberg

万古霉素耐药肠球菌(VRE)是引起医院感染的病原菌之一，因其多重耐药而成为感染控制的重点。因此，被VRE定植或感染的患者通常在基本措施之外受到广泛的感染控制措施，这导致了经济和临床负担。然而，这些控制措施的证据很少，还有待继续讨论。特别是在巴登-符腾堡州，发现整个德国的发病率增幅最高。医疗保健网络中迫切需要的VRE时空分析缺失。在两步联合项目巴登-符腾堡州VRE网络，包括四所大学医院以及地区医疗保健提供者和社区医院的过程中，我们打算进行这样的分析，为个别医疗保健中心和州政府的明智决策创造证据。需要对感染控制干预措施进行评估和严格评估，需要对风险因素进行分析，以了解德国南部乃至整个德国的VRE疫情。在该项目的第一阶段，将建立一个科学网络。巴登-符腾堡州VRE网络的目标是：(1)评估和分析包括所有与VRE相关的大学医院在内的区域医疗网络中的流行病学指标和患者转移数据；(2)系统的文献综述，评估VRE作为感染源的相关性，包括致病性、传播性、定居的重要性和持续时间以及VRE感染的风险因素；(3)巴登-符腾堡州内感染控制措施的标准化和网络合作伙伴之间的更密切合作。该网络将奠定基础，促进成员之间的科学交流，制定感染控制的最佳做法建议和转移模式，以进一步加强遏制VRE疫情的政策。此外，该网络旨在准备科学研究建议，用全基因组分析来分析VRE的传播。

Vancomycin-resistant Enterococci (VRE) are one of pathogens causing nosocomial infections which are in the focus of infection control due to their multidrug-resistance. Patients colonized or infected with VRE are therefore usually subject to extensive infection control measures beyond basic measures, which results in financial and clinical burden. The evidence for these control measures is, however, low and subject to ongoing discussions. Especially in the state of Baden-Württemberg the highest increase in incidence rates of whole Germany has been detected. Urgently needed spatial-temporal analyses of VRE in the healthcare networks are missing. In the course of the two-step joint project VRE network Baden-Württemberg, which includes the four university hospitals as well as regional healthcare providers and community hopsitals, we intend to undertake such analyses to create evidence for informed decision making for both individual healthcare centers and state administration. Infection control interventions need to be evaluated and critically appraised and risk factors need to be analysed to understand the VRE epidemic in Southern Germany and hopefully in all of Germany.During the first phase of the project a scientific network will be created. The goals of the VRE network Baden-Württemberg are: (1) assess and analyze epidemiological indicators and patient transferal data in the regional healthcare networks including all universities hospitals related to VRE, (2) systematic literature review assessing the relevance of VRE as infectious agent including pathogenicity, transmissibility, importance and duration of colonization and risk factors for VRE infection, (3) standardization of infection control measures within Baden-Württemberg and closer collaboration between network partners. The network will lay down the foundation to foster scientific exchange between members, the development of best-practice-recommendations for infection control and transferal patterns to further strengthen the policy to stop the VRE epidemic. Furthermore, the network aims to prepare scientific research proposals to analyze the VRE transmission with whole-genome analysis.