Physiological impact of ClpP modulators on bacteria and mitochondria (A01)

酪蛋白分解蛋白酶Clp在细菌和线粒体中的蛋白质稳态和调节蛋白水解中起核心作用，并且是抗菌、抗毒力和抗肿瘤治疗的靶标。我们研究了两类调节剂的复合蛋白酶的蛋白水解核心ClpP。ADEP抗生素激活ClpP并导致蛋白质消化失控。在这里，我们探索改变的底物光谱。对于一类抑制ClpP的新天然产物，我们研究了生产者自我保护的机制。

The caseinolytic protease Clp plays a central role in protein homeostasis and regulatory proteolysis in bacteria and mitochondria and is a target for antibacterial, anti-virulence, and antitumor therapy. We investigate two classes of modulators of the proteolytic core ClpP of the complex protease. ADEP antibiotics activate ClpP and lead to uncontrolled protein digestion. Here, we explore the altered substrate spectrum. For a new natural product class inhibiting ClpP, we investigate the mechanism of producer self-protection.