Consequences of formyl-peptide receptor activation to the skin (A08)

白细胞通过甲酰肽受体(FPR)感知甲酰化肽。葡萄球菌皮肤共生体和病原体分泌苯酚可溶性调制素(PSM)多肽，FPR2的强激动剂。在小鼠感染金黄色葡萄球菌的早期，FPR2对白细胞的募集起重要作用。尽管FPR2在人类角质形成细胞和皮肤成纤维细胞上也有表达，但对这些细胞中FPR2激活的后果几乎一无所知。我们的目的是阐明FPR和FFR激活配体在原代角质形成细胞和皮肤成纤维细胞的炎症反应和信号转导中的作用。我们将使用细胞培养和皮肤伤口愈合、感染和系统性硬化症的小鼠模型来评估FPR作为预防或治疗皮肤疾病的靶点的潜力。

Leukocytes sense formylated peptides via formyl-peptide receptors (FPRs). Staphylococcal skin commensals and pathogens secrete phenol-soluble modulin (PSM) peptides, strong agonists of FPR2. FPR2 is important for the recruitment of leukocytes in early infections with S. aureus in mice. Although FPR2 is expressed also on human keratinocytes and skin fibroblasts, nearly nothing is known about the consequence of FPR activation in these cells. Our aim is to elucidate the role of FPRs and FPR-activating ligands in the inflammatory responses and in signal transduction in primary keratinocytes and skin fibroblasts. We will use cell culture and mouse models of skin wound healing, infection and systemic sclerosis to assess the potential of FPRs as targets for the prevention or therapy of skin diseases.