Crosstalk between the mitochondrial respiratory chain and the cytosolic protein synthesis machinery (B05)

线粒体在细胞新陈代谢中发挥重要作用。线粒体呼吸链对于氧化磷酸化是必不可少的，而功能障碍会导致活性氧物种的急剧增加。我们发现，线粒体产生的活性氧水平的增加会导致细胞质蛋白质合成机制的快速抑制。在项目B5中，我们将研究这种重要的细胞内串扰背后的机制以及翻译是如何被调制的。我们的发现将有助于更好地理解人类病理中的线粒体功能障碍。

Mitochondria fulfill important functions in cellular metabolism. The mitochondrial respiratory chain is essential for oxidation phosphorylation and dysfunction can lead to a drastic increase in reactive oxygen species. We showed that increased levels of mitochondria-produced reactive oxygen species result in a fast inhibition of the cytosolic protein synthesis machinery. In project B5, we will study the mechanisms underlying this important intracellular crosstalk and how translation is modulated. Our findings will contribute to a better understanding of mitochondrial dysfunction in human pathologies.