high-resolution, peripheral, quantitative computed tomography scanner - in vivo MicroCT Scanner

BY申请的高分辨率、外围、定量的计算机断层扫描仪将通过多学科应用，帮助回答骨学、生物力学和整形外科的临床和基础科学问题。第一个项目的重点是诊断和调查伴有矿化缺陷的骨骼疾病，这种缺陷会导致骨骼的机械能力降低，导致高骨折风险。该项目的目的是使用非常高分辨率的虚拟骨活检作为一种新的诊断工具，以取代介入性组织样本。第二部分的病灶是关节软骨中的矿物晶体，与关节关节炎的严重程度有关，缺乏早期诊断方法。该项目的目的是通过高分辨率外围定量计算机断层扫描来预测关节关节病的进展和关节置换的必要性，这种成像能够识别和表征关节炎关节软骨中的矿化晶体结构。第三个项目集中于椎体骨折，导致疼痛和发病率增加。这些骨折仍然是骨质疏松症最常见的骨折之一，其机制仍不完全清楚。该项目的目的是将椎体的失效机制与其结构和骨材料质量的背景更紧密地联系起来。基于有限元方法的模拟将用于分离骨结构和材料特性，并随后巩固这些结果。

The high-resolution, peripheral, quantitative computed tomography scanner applied for by will help to answer clinical and basic science questions in osteology, biomechanics and orthopedics through a multidisciplinary application. The focus of the first project is on the diagnosis and investigation of bone diseases with mineralization defect that causes a reduced mechanical capacity of the bone, leading to a high fracture risk. The aim of this project is to use virtual bone biopsies at very high resolution as a new diagnostic tool instead of the interventional tissue sample. Focus of the second part are mineral crystals in the joint’s cartilage, which are associated with the severity of joint arthritis, lacking methods for early diagnosis. The aim of this project is to predict the progression of joint arthrosis and the necessity of joint replacement by means of high-resolution peripheral, quantitative computer tomography that allows for identifying and characterizing mineralized crystal formations in the joint cartilage of arthritic joints. The third project concentrates on vertebral body fractures, causing pain and increasing morbidity. These fractures are still one of the most common fractures in osteoporosis and their mechanisms are still not fully understood. The aim of this project is to relate the failure mechanisms of vertebral bodies more closely to the context of their structure and bone material quality. A finite element method-based simulation will be used to separate bone structure and material properties and subsequently consolidate these results.