Functional Characteristics of Neonatal Naive T cell and Their Maturation into Memory T cell

幼稚T细胞群和记忆T细胞群可以通过CD45亚型的差异表达来区分。这些研究是为了阐明新生儿先天幼稚T细胞的一些功能特征，以及它们在出生后抗原暴露增加后进入记忆T细胞的成熟步骤。所得结果如下：1)尽管新生T细胞与成人幼稚T细胞在CD45RA表达方面有共同之处，但它们具有较强的抑制活性，即使在激活后发生记忆细胞样表型改变后，对B细胞分化的辅助活性也较低。2) T-gamma/delta^+ T细胞中的BB3^+亚群，而不是delta - cs -1^+细胞中的BB3^+亚群，表达CD45RO并对抗原有应答能力。3)幼稚的CD4^+ T细胞，与记忆细胞不同，对抗cd2刺激的反应较低，这是基于它们不能产生il 6.4) CD4^+和CD8^+ T细胞群都表达CD45RO和HLA-DR抗原，表明爱泼斯坦-巴尔感染的强烈刺激。5)记忆T细胞表达IL-2受体亚单位（α或链）并对外源性il -反应良好2.6)在新生儿和幼儿的血液中可识别出具有表达IL-2R α链的幼稚（CD45RA^+, CD45RO^-）表型的CD4^+ T细胞群，其表达记忆样功能。这个群体代表了从幼稚T细胞到记忆T细胞过渡阶段的细胞。7)足月新生儿对细菌病原体可产生IL-6，但早产儿产生IL-6的能力尚不成熟。

Naive and memory T cell populations can be discriminated by differential expression of CD45 isoforms. These studies were undertaken to elucidate some functional characteristics of neonatal inherently naive T cells and their maturation steps into memory T cells following increased antigenic exposure after birth. Obtained results are follow as.1) Although neonatal T cells share with adult naive T cells in terms to CD45RA expression, they have strong suppressor activity and less helper activity for B cell differentiation even after memory cells-like phenotypic changes by activation.2) BB3^+ subsets within T-gamma/delta^+ T cells, but not deltaTCS-1^+ cells, express CD45RO and have the ability to respond to the antigen.3) Naive CD4^+ T cells, unlike memory ones, are hyporesponsive to anti-CD2 stimulation, based on their inability to produce IL-6.4) Both CD4^+ and CD8^+ T cell populations express CD45RO as well as HLA-DR antigens, indicating strong stimulation with Epstein-Barr infection.5) Memory T cells express IL-2 receptor subunits (alpha or chains) and respond well to exogenous IL-2.6) A novel population of CD4^+ T cells with naive (CD45RA^+, CD45RO^-) phenotype expressing IL-2R alpha-chain, which express memory-like functions, are identifiable in the blood of newborns and young children. This population represents the cells at the transitional stage from naive to memory T cells.7) Full-term newborns can produce IL-6 in response to bacterial pathogens, but IL-6-producing capabilities of preterm babies are still immature.