Novel ligand synthesis for molecular recognition and analysis of the recognition systems

目前，在许多化学领域都需要设计用于金属选择性螯合的配体。对选择性原理的理解对于理解生物阳离子运输系统、金属离子结合蛋白以及金属离子如何在环境中分布所表现出的金属离子选择性是非常宝贵的。我们提出的识别概念是：常规有机配体的离子大小识别受几个参数的控制。第一种是基于供体原子之间的距离，即咬尺寸。第二个是螯合环的刚性。

There is at present a need in several chemical fields toward ligand design for selectiv chelation of metals. And an understanding of the principles of selectivety would be invaluable in understanding the metal ion selectivity displayd by biological cation transport systems, metal ion binding proteins and how metal ions are distributed in the environment. The recognition concept proposed by us is as follows : The ion size recognition with conventional organic ligands is governed by a few parameters. The first is based on the distance between donor atoms, that is, bite size. And the second is the rigidity of the chelate ring.