Effects trihalometane and clorinated orgnic solvents for the enviroment and ecology.

为了模拟三氯乙烯（TRI）的吸收分布和排泄，以及TRI代谢产物形成和消除的药代动力学研究，犬吸入TRI 700 ppm，持续1 h，并给予TRI代谢产物（水合氯醛、三氯乙醇和三氯乙酸）。重复测定呼气、动脉血和静脉血中TRI浓度。测定血清、尿液和胆汁中水合氯醛（CH）、三氯乙酸（TCA）和三氯乙醇（TCE）的浓度。在700 ppm时，TRI的吸收量为54.6mg/kg，在1h的时间内吸收率约为40%。暴露后1h呼气中累积排泄量为21.0mg/kg。从暴露开始后即刻至暴露结束后1h，尿和胆汁中总三氯化合物代谢产物的排泄率约为TRI吸收体积的1.4%。暴露结束后1h，约有18%的吸附TRI被代谢为CH、tce和TCA。

In order to simulate the absorption distribution and excretion of trichloroethlene (TRI), as well as the pharmacokinetics study of formation and elimination of TRI metabolites, TRI was inhaled by dogs for one hour at 700 ppm and TRI metabolites (chloral hydrate, trichloroethanol and trichloroacetic acid) were administered to dogs. TRI concentrations in expired air, arterial blood and venous blood were repeatedly measured. Chloral hydrate (CH), trichloroacetic acid (TCA) and trichloroethanol (TCE) concentrations in serum, urine and bile were also measured. Absorption of TRI was 54.6 mg/kg at 700 ppm and absorption ratio was about 40 % during one hour esposure. The cumulative excretion values in expired air one hour after exposure was 21.0mg/kg. The excretion rate of metabolites from urine and bile for total-trichlorocompounds to the absorbed volume of the TRI from immediately after the start of exposure until one hour after the end of exposure was about 1.4%.Acoording to TRI exposure study and others, pharnacokinetics studies were made. About 18% of avsorbed TRI was metabolized to CH, tce and TCA for one hour after the end of exposure.