Clinical Significance of Brain Natriuretic Peptide (BNP) in Cardiac Diseases

本研究的目的是阐明脑利钠肽（BNP）在各种心脏疾病中的临床意义，与心房利钠肽（ANP）相比。正常人血浆BNP水平为2-4pg/ml，约为ANP的1/5，但在高血压、Chrome肾功能衰竭、充血性心力衰竭综合征等病理状态下，血浆BNP水平明显升高，超过ANP水平，血浆BNP水平可作为心脏疾病的预后指标。血浆ANP来源于心房，而血浆BNP来源于心室。结论：BNP仅在急性应激时由心室分泌。这可能是病理状态下减轻前后负荷的心脏代偿机制之一。

The objective of the present investigation was to clarify the clinical significance of brain natriuretic peptide (BNP) in various cardiac diseases compared to that of atrial natriuretic peptide (ANP). Plasma BNP levels in normal subjects were 2-4pg/ml, which were one-fifth those of ANP.However, under pathological conditions, such as hypertension, chrome renal failure, congestive heart distress syndrome, plasma BNP levels were remarkably elevated which exceeded those of ANP.Plasma BNP levels showed prognostic marker for cardiac deseases. While plasma ANP was derived from atria, plasma BNP was it is concluded that BNP is exclusively secreted from ventricle in response to acute stress. Which may function as one of the cardiac compensatory mechanisms to reduce both pre-and after load under the pathological states.