RESEARCHES ON IMPROVEMENT OF PERTUSSIS VACCINE

在日本，含无细胞百日咳疫苗的DTP疫苗完全取代了含全细胞百日咳疫苗的DTP疫苗。此后，第三剂百日咳疫苗的接受率一直保持在80%以上。百日咳在日本稳步下降。本研究的目的是评价日本目前的无细胞百日咳疫苗。用最灵敏的ELISA法评价对无细胞疫苗的抗体应答，并评价二次攻击率。一个研究小组对百日咳患者进行了全国性调查，得出的结论是，接种三剂无细胞百日咳疫苗的儿童显示出与自然感染百日咳的儿童相当的抗体反应。通过家庭接触研究的二次发病率研究表明，无细胞百日咳疫苗非常有效。

In Japan DTP vaccine containing acellular pertussis vaccine totally replaced DTP which contained whole cell pertussis vaccine. Since then acceptance rates of third doses of pertussis vaccine remained over 80%. Pertussis has steadily decreased in Japan. The purpose of this study was to evaluate current acellular pertussis vaccine in Japan. Antibody responses to acellular vaccines were evaluated by the most sensitive ELISA.Secondary attack rates were evaluated. National survey of the pertussis patients was performed by a research team.It was concluded that children given three doses of acellular pertussis vaccine showed antibody responses comparable to those who contracted natural pertussis infection. Studies on secondary attack rates by family contact study revealed the acellular pertussis vaccine was very effective.