Regulatory mechanism of dopamine metabolism in rat brain.

1.观察了大鼠给药后多巴胺(DA)及其代谢产物(DOPAC和HVA)浓度的变化。结果表明，第一天HVA的增加早在第三天就明显减弱，到第11天在额叶皮质、尾壳核和杏仁核几乎平行地减弱。(1)测定了大鼠左侧内嗅皮层损毁后DA及其代谢产物的浓度。(2)用体内微透析法测定了急性给予甲基苯丙胺对损毁大鼠左侧杏仁核DA释放的影响。结果表明：(1)术后第28天，杏仁核外侧区DA含量较对照组升高。(2)损毁组大鼠左侧杏仁核DA释放量显著高于对照组。这些结果表明，损毁内嗅皮层的大鼠可能是研究精神分裂症中DA过度活动的动物模型。

1.Changes in concentrations of dopamine (DA) and its metabolites (DOPAC and HVA) follwing haloperidol decanoate administration in rat were investigated. The results showed that the initial increase in HVA on day 1 had significantly attenuated as early as day 3 and diminished further on day 11 almost in parallel in the frontal cortex, caudate-putamen, and amygdala.2.(1) Concentration of DA and its metabolites following the left entorhinal cortex lesion in rat brain were datermined and (2) The effects of acute administration of methamphetamine on DA release in the left amygdala in lesioned rats was measured by the in vivo microdialysis method. The results showed that (1) the only change on the 28th postoperative day was the increased concentration of DA in the lateral amygdala compared with the controls. (2) The DA release in the left amygdala in the lesioned rats was significantly higher than that in the controls. These results suggest that the entorhinal cortex lesioned rats may be useful for an animal model to study DA overactivity in schizophrenia.