Long-Term Follow-up Study of Patients with Persistent Sleep-Wake Rhythm Disorders and Social Maladjustment

我们调查了接受强化治疗的持续性睡眠-觉醒时间障碍患者的治疗反应和长期病程。调查是通过邮寄问卷和使用他们目前的睡眠状况和社会状态的医院记录来进行的。以10例青少年（7例延迟睡眠阶段综合征，3例非24小时睡眠-觉醒综合征）和14例成人延迟睡眠阶段综合征为研究对象，随访时间为初始治疗后1.2 ~ 11.2年。在青少年和成人中，社会适应水平的改善大于疾病严重程度的改善。所有患者（21例青少年7例，成人14例）在社会适应和病情严重程度方面均有显著改善。对这些持续性睡眠-觉醒节律障碍患者的随访显示，强化干预后持续改善。这些发现表明，需要长期随访来判断治疗效果，并需要更多的病例研究，以了解影响这些疾病发病机制和预后的因素。

We investigated the response to treatment and long-term course of patients with persistent sleep-wake schedule disorders who had formly received intensive treatment. The investigation was carried out with mailed questionnaires and the use of their hospital records about current sleep conditions and social state. Ten adolescents (7 delayd sleep phase syndrome (DSPS) , 3 non-24-hour sleep-wake syndrome) and 14 adults with delayd sleep phase syndrome were subjects and the follow-ups were obtained from 1.2 to 11.2 years after the initial treatment.Improvement in the social adaptation level was greater than improvement in the illness severity level in both adolescents and adults. All the DSPS patients (21 cases ; 7 adolescents and 14 adults) showed significant improvement in both the social adaptation and the illness severity. A follow up of these patients with persistent sleep-wake rhythm disorders showed consistent improvement after intensive intervention. These findings suggest that a long-term follow-up is needed to judge the effect of the treatment and more cases should be studied to learn with factors influence the pathogenesis and the prognosis of these disorders.